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Thursday, March 10, 2011

Avandia Side Effects - Getting Compensated for Avandia's Dangerous Side Effects

By Frank Bruner

We all know that Diabetes is a serious medical condition. It needs to be treated in a timely and adequate manner. If you don't treat the condition, it can lead to grave damages to the cardiovascular system as well as to other vital organs in the body. Diabetes Rosiglitazone drugs, such as Avandia, Avandamet and Avandaryl brand names are actually considered as very effective medications for Type 2 diabetes. However, there is much controversy about their serious side effects, particularly on the heart and on the cardiovascular system.

Diabetes Rosiglitazone medications work in increasing the responsiveness of the body's fat cells to insulin. It is the molecules of the chemical compound which attacks the PPAR receptors within the fat cells - making them even more sensitive to insulin. This is done in order for them to process effectively. It is for this reason that these medications became known as "sensitizers".

We can find a majority of fat cells which these drugs affect not only in the liver but also in the heart muscles and in the blood vessel walls as well as in various muscles in the body. Due to this, scientists are researching further about the effects of these drugs on the mentioned organs.

There was a 2007 study which showed how Avandia can increase the risks of heart attack by about 43%. Even in the United States, their Food and Drug Administration (FDA) was able to link more than 83,000 cases of heart attack. It is noted that these occurred between the years 1999 and 2007 to users of the drug, Rosiglitazone.

Another study, the results of which were published in 2010, revealed that the drug may increase the risk of stroke by 27%. Still, it should be pointed out that several other studies have found an insignificant increase in risk of heart attack and stroke in patients taking these medications.

Following the initial findings of the study in 2007 and from the warnings given by physicians who are treating patients taking diabetes drugs, the FDA took action and reviewed Avandia last 2007. After being reviewed, the FDA advisory panel then concluded that the risk of using Rosiglitazone drug and cause heart attack as well as stroke was actually statistically insignificant. The manufacturing company still decided it best to add a black-box warning on their drug's labels.

Though this was the conclusion of the FDA, there are still controversies about using the medication. It was even announced last September 2010 that the United Kingdom's Commission on Human Medicines recommends the respective regulatory body in the UK to withdraw these drugs on the shelves of drugstores. Their reason: "the risks outweigh the benefits."

Even though the debate about the risk of Avandia and the other Rosiglitazone drugs causing heart attack is ongoing, the manufacturing company's lawyers have announced that the manufacturer faces Avandia lawsuits from users who claim they have not been warned about the potential side effects.

Lawyers of these plaintiffs actually based their cases on the mere fact that the black-box warning pertaining to the risks of heart attack was not on the label until year 2007. As for Rosiglitazone drugs, they had been on the shelves of drugstores for a very long period of time. Like for Avandia, it obtained its patent and then, it was introduced last 1999.

Diabetics or Diabetes patients should be informed about any potential side effects of the drugs they are taking. It should be pointed out that there should be discussions with your doctor about your particular situation. This is important so that they can recommend you the most effective as well as the safest treatment for your case.

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